CGP 35348

Ligand id: 1069

Name: CGP 35348

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 91.59
Molecular weight 225.11
XLogP -0.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bowery NG, Bettler B, Froestl W, Gallagher JP, Marshall F, Raiteri M, Bonner TI, Enna SJ. (2002)
International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyricacid(B) receptors: structure and function.
Pharmacol Rev.54: 247-264. [PMID:12037141]
2. Froestl W, Mickel SJ, von Sprecher G, Diel PJ, Hall RG, Maier L, Strub D, Melillo V, Baumann PA, Bernasconi R et al.. (1995)
Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
J. Med. Chem.38: 3313-3331. [PMID:7650685]
3. Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B. (1997)
Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors.
Nature386: 239-246. [PMID:9069281]
4. Wood MD, Murkitt KL, Rice SQ, Testa T, Punia PK, Stammers M, Jenkins O, Elshourbagy NA, Shabon U, Taylor SJ, Gager TL, Minton J, Hirst WD, Price GW, Pangalos M. (2000)
The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
Br J Pharmacol131: 1050-1054. [PMID:11082110]