Ligand Id: 1346
Ligand name 6-Cl-MLT

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 54.12
Molecular weight 266.08
XLogP 1.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Audinot, V., Mailliet, F., Lahaye-Brasseur, C., Bonnaud, A., Le Gall, A., Amossé, C., Dromaint, S., Rodriguez, M., Nagel, N., Galizzi, J. P., Malpaux, B., Guillaumet, G., Lesieur, D., Lefoulon, F., Renard, P., Delagrange, P. and Boutin, J. A. (2003)
New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Naunyn Schmiedebergs Arch Pharmacol, 367: 553-561. [PMID:12764576]
2. Dubocovich, M. L., Masana, M. I., Iacob, S. and Sauri, D. M. (1997)
Melatonin receptor antagonists that differentiate between the human Mel1aand Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.
Naunyn Schmiedebergs Arch. Pharmacol., 355: 365-375. [PMID:9089668]
3. Beresford, I. J., Browning, C., Starkey, S. J., Brown, J., Foord, S. M., Coughlan, J., North, P. C., Dubocovich, M. L. and Hagan, R. M. (1998)
GR196429: a nonindolic agonist at high-affinity melatonin receptors.
J Pharmacol Exp Ther, 285: 1239-1245. [PMID:9618428]