ramelteon

Ligand id: 1356

Name: ramelteon

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 38.33
Molecular weight 259.16
XLogP 3.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Kato K, Hirai K, Nishiyama K, Uchikawa O, Fukatsu K, Ohkawa S, Kawamata Y, Hinuma S, Miyamoto M. (2005)
Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist.
Neuropharmacology48: 301-310. [PMID:15695169]
2. Rawashdeh O, Hudson RL, Stepien I, Dubocovich ML. (2011)
Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice.
Chronobiol. Int.28 (1): 31-8. [PMID:21182402]