DCG-IV

Ligand id: 1377

Name: DCG-IV

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 137.92
Molecular weight 203.04
XLogP -4.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Brabet I, Parmentier ML, de Colle C, Bockaert J, Acher F, Pin JP. (1998)
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Neuropharmacology.37: 1043-1051. [PMID:9833633]
2. Cartmell J, Adam G, Chaboz S, Henningsen R, Kemp JA, Klingelschmidt A, Metzler V, Monsma F, Schaffhauser H, Wichmann J, Mutel V. (1998)
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
Br J Pharmacol.123: 497- 504. [PMID:9504391]
3. Johnson BG, Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. (1999)
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
Neuropharmacology.38: 1519- 1529. [PMID:10530814]
4. Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RLM, Mutel V. (1999)
Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.
Brain Res. Mol. Brain Res.67: 201-210. [PMID:10216218]
5. Mutel V, Ellis GJ, Adam G, Chaboz S, Nilly A, Messer J, Bleuel Z, Metzler V Malherbe Schlaeger EJ, Roughley BS, Faull RL, Richards JG. (2000)
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
J Neurochem.75: 2590-2601. [PMID:11080213]
6. Schweitzer C, Kratzeisen C, Adam G, Lundstrom K, Malherbe P, Ohresser S, Stadler H, Wichmann J, Woltering T, Mutel V. (2000)
Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.
Neuropharmacology.39: 1700- 1706. [PMID:10884552]
7. Wright RA, Arnold MB, Wheeler WJ, Ornstein PL, Schoepp DD. (2000)
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
Naunyn Schmiedebergs Arch Pharmacol.362: 546-554. [PMID:11138847]