Ligand Id: 147
Ligand name DOI

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 44.48
Molecular weight 321.02
XLogP 2.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands Radio analogues
References
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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
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Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.
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Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.
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[3H]-DOB(4-bromo-2,5-dimethoxyphenylisopropylamine) and [3H] ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor.
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Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors.
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Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.
Mol Pharmacol, 46: 227-234. [PMID:8078486]
8. Wainscott, D. B., Cohen, M. L., Schenck, K. W., Audia, J. E., Nissen, J. S., Baez, M., Kursar, J. D., Lucaites, V. L. and Nelson, D. L. (1993)
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
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Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.
Br J Pharmacol, 140: 277-284. [PMID:12970106]
10. Egan, C., Grinde, E., Dupre, A., Roth, B. L., Hake, M., Teitler, M. and Herrick-Davis, K. (2000)
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors.
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