cicaprost

Ligand id: 1917

Name: cicaprost

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 86.99
Molecular weight 374.21
XLogP 1.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Abramovitz M, Adam M, Boie Y, Carriere M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM. (2000)
The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogues.
Biochim. Biophys. Acta.1483: 285-293. [PMID:10634944]
2. Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S. (1997)
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
Br. J. Pharmacol.122: 217-224. [PMID:9313928]
3. Wang JW, Vu C, Poloso NJ. (2017)
A Prostacyclin Analog, Cicaprost, Exhibits Potent Anti-Inflammatory Activity in Human Primary Immune Cells and a Uveitis Model.
J Ocul Pharmacol Ther,  [Epub ahead of print]. [PMID:28072560]