SB 242084

Ligand id: 193

Name: SB 242084

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 67.35
Molecular weight 394.12
XLogP 3.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP. (1997)
SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.
Neuropharmacology, 36: 609-620. [PMID:9225286]
2. Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. (2004)
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Naunyn Schmiedebergs Arch Pharmacol, 370: 114-123. [PMID:15322733]