R3/I5   Click here for help

GtoPdb Ligand ID: 1998

Synonyms: H3 relaxin B-chain/INSL5 A-chain chimera | H3 relaxin/INSL5 chimera | H3-B/INSL5 A chimera
Compound class: Peptide or derivative
Comment: Synthetic peptide consisting of human relaxin-3 (B chain) and human INSL5 (A chain). For the amino acid sequences of the subunits, please see their individual ligand entries.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Ganella DE, Callander GE, Ma S, Bye CR, Gundlach AL, Bathgate RA. (2013)
Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus.
Gene Ther, 20 (7): 703-16. [PMID:23135160]
2. Kuei C, Sutton S, Bonaventure P, Pudiak C, Shelton J, Zhu J, Nepomuceno D, Wu J, Chen J, Kamme F et al.. (2007)
R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.
J Biol Chem, 282 (35): 25425-35. [PMID:17606621]
3. Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW. (2005)
Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.
Mol Pharmacol, 67 (1): 231-40. [PMID:15465925]
4. Wang JH, Shao XX, Hu MJ, Liu YL, Xu ZG, Guo ZY. (2019)
Functionality of an absolutely conserved glycine residue in the chimeric relaxin family peptide R3/I5.
Amino Acids, 51 (4): 619-626. [PMID:30604098]