[125I]LTT-SRIF-28   Click here for help

GtoPdb Ligand ID: 2023

Synonyms: 3-[125I](Leu8, D-Trp22, Tyr25)somatostatin-28 | 3-[125I]LTT-SRIF-28 | [125I](Leu8, D-Trp22, Tyr25)-somatostatin-28
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Corness JD, Demchyshyn LL, Seeman P, Van Tol HH, Srikant CB, Kent G, Patel YC, Niznik HB. (1993)
A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
FEBS Lett, 321 (2-3): 279-84. [PMID:8097479]
2. Feuerbach D, Fehlmann D, Nunn C, Siehler S, Langenegger D, Bouhelal R, Seuwen K, Hoyer D. (2000)
Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor.
Neuropharmacology, 39 (8): 1451-62. [PMID:10818261]
3. Reubi JC, Perrin M, Rivier J, Vale W. (1982)
High affinity binding sites for somatostatin to rat pituitary.
Biochem Biophys Res Commun, 105 (4): 1538-45. [PMID:6125148]
4. Reubi JC, Perrin MH, Rivier JE, Vale W. (1981)
High affinity binding sites for a somatostatin-28 analog in rat brain.
Life Sci, 28 (19): 2191-8. [PMID:6114372]
5. Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F et al.. (1998)
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Science, 282 (5389): 737-40. [PMID:9784130]
6. Siehler S, Seuwen K, Hoyer D. (1998)
[125I]Tyr10-cortistatin14 labels all five somatostatin receptors.
Naunyn Schmiedebergs Arch Pharmacol, 357 (5): 483-9. [PMID:9650799]
7. Siehler S, Seuwen K, Hoyer D. (1998)
[125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors.
Eur J Pharmacol, 348 (2-3): 311-20. [PMID:9652348]
8. Siehler S, Seuwen K, Hoyer D. (1999)
Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.
Naunyn Schmiedebergs Arch Pharmacol, 360 (5): 488-99. [PMID:10598788]