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Synonyms: [111In-DOTA]-NOC [1] | [InIII-DOTA]-NOC | [InIII-DOTA]-NOC
Compound class:
Peptide or derivative
Comment: Synthetic radiolabelled peptide. The amino acid sequence of octreotide (FCFWKTCT) is modified by replacing the phenylalanine residue at position 3 with 3-naphthylalanine. The peptide is conjugated with DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) and radiolabelled with indium (111I). The structure of the unlabelled form of this peptide is shown in the reference.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Ginj M, Chen J, Walter MA, Eltschinger V, Reubi JC, Maecke HR. (2005)
Preclinical evaluation of new and highly potent analogues of octreotide for predictive imaging and targeted radiotherapy. Clin Cancer Res, 11 (3): 1136-45. [PMID:15709181] |
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2. Wild D, Schmitt JS, Ginj M, Mäcke HR, Bernard BF, Krenning E, De Jong M, Wenger S, Reubi JC. (2003)
DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging, 30 (10): 1338-47. [PMID:12937948] |
