trifluoperazine

Ligand id: 214

Name: trifluoperazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 35.02
Molecular weight 407.16
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL. (2003)
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
Neuropsychopharmacology28: 519-526. [PMID:12629531]
2. Seeman P, Corbett R, Van Tol HH. (1997)
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
Neuropsychopharmacology16 (2): 93-110; discussion 111-35. [PMID:9015795]