tyramine

Ligand id: 2150

Name: tyramine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 46.25
Molecular weight 137.08
XLogP 0.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR. (2008)
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
Mol Pharmacol, 74: 585-594. [PMID:18524885]
2. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C. (2001)
Trace amines: identification of a family of mammalian G protein-coupled receptors.
Proc Natl Acad Sci U S A, 98: 8966-8971. [PMID:11459929]
3. Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, Wettstein JG, Pinard A, Buchy D, Gassmann M, Hoener MC et al.. (2009)
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.
Proc. Natl. Acad. Sci. U.S.A., 106 (47): 20081-6. [PMID:19892733]
4. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DK. (2001)
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor.
Mol Pharmacol, 60: 1181-1188. [PMID:11723224]
5. Engel K, Wang J. (2005)
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Mol. Pharmacol., 68 (5): 1397-407. [PMID:16099839]
6. Hu LA, Zhou T, Ahn J, Wang S, Zhou J, Hu Y, Liu Q. (2009)
Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.
Biochem. J., 424 (1): 39-45. [PMID:19725810]
7. Kleinau G, Pratzka J, Nürnberg D, Grüters A, Führer-Sakel D, Krude H, Köhrle J, Schöneberg T, Biebermann H. (2011)
Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.
PLoS ONE, 6 (10): e27073. [PMID:22073124]
8. Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, Grandy DK. (2007)
Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine.
J Pharmacol Exp Ther, 321: 178-186. [PMID:17218486]
9. Wainscott DB, Little SP, Yin T, Tu Y, Rocco VP, He JX, Nelson DL. (2007)
Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1.
J Pharmacol Exp Ther, 320: 475-485. [PMID:17038507]
10. Wang J. (2016)
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Clin. Pharmacol. Ther., 100 (5): 489-499. [PMID:27506881]
11. Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP. (2007)
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.
Genes Brain Behav, 6: 628-639. [PMID:17212650]