Ligand Id: 2176
Ligand name [3H]OT (human, mouse, rat)

2D Structure

Summary Biological activity References Structure Similar ligands Radio analogues
References
1. Phalipou, S., Cotte, N., Carnazzi, E., Seyer, R., Mahe, E., Jard, S. and Barberis, C. (1997)
Mapping peptide binding domains of the human V1a vasopressin receptor with a photoactivatable linear peptide antagonist.
J Biol Chem272: 26536-26544. [PMID:9334232]
2. Thibonnier, M., Preston, J. A., Dulin, N., Wilkins, P. L., Berti-Matera, L. N. and Mattera, R. (1997)
The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways.
Endocrinology.138: 4109-4122. [PMID:9322919]
3. Chini, B., Mouillac, B., Ala, Y., Balestre, M. N., Trumpp-Kallmeyer, S., Hoflack, J., Elands, J., Hibert, M., Manning, M., Jard, S. et al.. (1995)
Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor.
The EMBO Journal.14: 2176-2182. [PMID:7774575]
4. Kimura, T., Makino, Y., Saji, F., Takemura, M., Inoue, T., Kikuchi, T., Kubota, Y., Azuma, C., Nobunaga, T. and Tokugawa, Y. (1994)
Molecular characterization of a cloned human oxytocin receptor.
Eur J Endocrinol131: 385-390. [PMID:7921228]
5. Jasper, J. R., Harrell, C. M., O'Brien, J. A. and Pettibone, D. J. (1995)
Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells.
Life Sci57: 2253-2261. [PMID:7475979]
6. Fuchs, A. R., Fuchs, F., Husslein, P., Soloff, M. S. and Fernstrom, M. J. (1982)
Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor.
Science215: 1396-1398. [PMID:6278592]

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