apamin

Ligand id: 2311

Name: apamin

Structure and Physico-chemical Properties

2D Structure
References
1. Barfod ET, Moore AL, Lidofsky SD. (2001)
Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3.
Am. J. Physiol., Cell Physiol., 280 (4): C836-42. [PMID:11245600]
2. Church TW, Weatherall KL, Corrêa SA, Prole DL, Brown JT, Marrion NV. (2015)
Preferential assembly of heteromeric small conductance calcium-activated potassium channels.
Eur. J. Neurosci., 41 (3): 305-15. [PMID:25421315]
3. Hosseini R, Benton DC, Dunn PM, Jenkinson DH, Moss GW. (2001)
SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones.
J. Physiol. (Lond.), 535 (Pt 2): 323-34. [PMID:11533126]
4. Jäger H, Adelman JP, Grissmer S. (2000)
SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat.
FEBS Lett., 469 (2-3): 196-202. [PMID:10713270]
5. Kohler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J, Adelman JP. (1996)
Small-conductance, calcium-activated potassium channels from mammalian brain.
Science, 273 (5282): 1709-14. [PMID:8781233]
6. Shah M, Haylett DG. (2000)
The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines.
Br. J. Pharmacol., 129 (4): 627-30. [PMID:10683185]
7. Stocker M, Hirzel K, D'hoedt D, Pedarzani P. (2004)
Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations.
Toxicon, 43 (8): 933-49. [PMID:15208027]
8. Strøbaek D, Jørgensen TD, Christophersen P, Ahring PK, Olesen SP. (2000)
Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.
Br. J. Pharmacol., 129 (5): 991-9. [PMID:10696100]
9. Terstappen GC, Pula G, Carignani C, Chen MX, Roncarati R. (2001)
Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines.
Neuropharmacology, 40 (6): 772-83. [PMID:11369031]
10. Weatherall KL, Goodchild SJ, Jane DE, Marrion NV. (2010)
Small conductance calcium-activated potassium channels: from structure to function.
Prog. Neurobiol., 91 (3): 242-55. [PMID:20359520]
11. Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl DJ. (2004)
An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.
Mol. Pharmacol., 65 (3): 788-801. [PMID:14978258]