Ligand Id: 2341
Ligand name phorbol 12-myristate 13-acetate

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 130.36
Molecular weight 616.4
XLogP 6.51
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Santi, CM; Ferreira, G; Yang, B; Gazula, VR; Butler, A; Wei, A; Kaczmarek, LK; Salkoff, L. (2006)
Opposite regulation of Slick and Slack K+ channels by neuromodulators.
J. Neurosci., 26 (19): 5059-68. [PMID:16687497]
2. Mao, J; Wang, X; Chen, F; Wang, R; Rojas, A; Shi, Y; Piao, H; Jiang, C. (2004)
Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C.
Proc. Natl. Acad. Sci. U.S.A., 101 (4): 1087-92. [PMID:14732702]
3. Watanabe, H; Davis, JB; Smart, D; Jerman, JC; Smith, GD; Hayes, P; Vriens, J; Cairns, W; Wissenbach, U; Prenen, J; Flockerzi, V; Droogmans, G; Benham, CD; Nilius, B. (2002)
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
J. Biol. Chem., 277 (16): 13569-77. [PMID:11827975]
4. Xu, F; Satoh, E; Iijima, T. (2003)
Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.
Br. J. Pharmacol., 140 (2): 413-21. [PMID:12970074]