Synonyms: phosphatidylinositol-3,4,5-trisphosphate
Compound class:
Metabolite or derivative
Comment: There is some ambiguity in the literature and on online resources as to the exact structure and stereochemistry of this compound. Other representations include CID 24755492, and CID 53477782.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998)
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273 (8): 4465-9. [PMID:9468499] |
2. Brady JD, Rich ED, Martens JR, Karpen JW, Varnum MD, Brown RL. (2006)
Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci USA, 103 (42): 15635-40. [PMID:17032767] |
3. Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y, Liu F. (2000)
Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton. Proc Natl Acad Sci USA, 97 (10): 5089-94. [PMID:10792047] |
4. Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P. (2005)
Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J Biol Chem, 280 (47): 38923-31. [PMID:16172125] |
5. Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P et al.. (2008)
rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J Biol Chem, 283 (44): 30351-62. [PMID:18728011] |