Ligand Id: 2388
Ligand name putrescine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 52.04
Molecular weight 88.1
XLogP -0.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Yang, J; Jan, YN; Jan, LY. (1995)
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.
Neuron, 14 (5): 1047-54. [PMID:7748552]
2. Ishihara, K; Hiraoka, M; Ochi, R. (1996)
The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells.
J. Physiol. (Lond.), 491 ( Pt 2): 367-81. [PMID:8866861]
3. Lopatin, AN; Makhina, EN; Nichols, CG. (1994)
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification.
Nature, 372 (6504): 366-9. [PMID:7969496]
4. Quinn, S. J., Ye, C. P., Diaz, R., Kifor, O., Bai, M., Vassilev, P. and Brown, E. M. (1997)
The calcium-sensing receptor: a target for polyamines.
Am J Physiol, 273: C1315-C1323. [PMID:9357776]