cisapride

Ligand id: 240

Name: cisapride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 86.05
Molecular weight 465.18
XLogP 2.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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[3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.
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5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.
Naunyn Schmiedebergs Arch Pharmacol363: 146-160. [PMID:11218067]
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Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
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[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.
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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.
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