nortriptyline

Ligand id: 2404

Name: nortriptyline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 12.03
Molecular weight 263.17
XLogP 8.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Auerbach SS, DrugMatrix® and ToxFX® Coordinator National Toxicology Program. 
National Toxicology Program: Dept of Health and Human Services.
Accessed on 02/05/2014. Modified on 02/05/2014. DrugMatrix, https://ntp.niehs.nih.gov/drugmatrix/index.html
2. Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. (2000)
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.
J Med Chem43: 1011-1018. [PMID:10715164]
3. Kobayashi T, Washiyama K, Ikeda K. (2004)
Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs.
Neuropsychopharmacology29 (10): 1841-51. [PMID:15150531]
4. Su S, Ohno Y, Lossin C, Hibino H, Inanobe A, Kurachi Y. (2007)
Inhibition of astroglial inwardly rectifying Kir4.1 channels by a tricyclic antidepressant, nortriptyline.
J. Pharmacol. Exp. Ther.320 (2): 573-80. [PMID:17071817]