diazoxide

Ligand id: 2409

Name: diazoxide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 66.91
Molecular weight 229.99
XLogP 1.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Inagaki N, Gonoi T, Clement JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. (1995)
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Science270 (5239): 1166-70. [PMID:7502040]
2. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y. (1996)
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
J. Biol. Chem.271 (40): 24321-4. [PMID:8798681]
3. Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y. (1997)
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
J. Physiol. (Lond.)499 ( Pt 3): 715-20. [PMID:9130167]