nicorandil

Ligand id: 2411

Name: nicorandil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 94.36
Molecular weight 211.06
XLogP 0.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Nakae I, Matsumoto T, Horie H, Yokohama H, Omura T, Minai K, Matsui T, Nozawa M, Takahashi M, Sugimoto Y et al.. (2000)
Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism.
J. Cardiovasc. Pharmacol.35 (6): 919-25. [PMID:10836727]
2. Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y. (1997)
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
J. Physiol. (Lond.)499 ( Pt 3): 715-20. [PMID:9130167]