Ligand Id: 2500
Ligand name 4α-PDD

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 21
Topological polar surface area 130.36
Molecular weight 672.46
XLogP 8.47
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Watanabe, H; Davis, JB; Smart, D; Jerman, JC; Smith, GD; Hayes, P; Vriens, J; Cairns, W; Wissenbach, U; Prenen, J; Flockerzi, V; Droogmans, G; Benham, CD; Nilius, B. (2002)
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
J. Biol. Chem., 277 (16): 13569-77. [PMID:11827975]
2. Xu, F; Satoh, E; Iijima, T. (2003)
Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.
Br. J. Pharmacol., 140 (2): 413-21. [PMID:12970074]