nisoldipine

Ligand id: 2524

Name: nisoldipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 107.77
Molecular weight 388.16
XLogP 4.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, K├╝hbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. (2000)
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.
J. Biol. Chem.275 (50): 39193-9. [PMID:10973973]
2. Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT. (2004)
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Cell119 (1): 19-31. [PMID:15454078]
3. Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N. (2003)
Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.
J. Biol. Chem.278 (42): 40837-41. [PMID:12900400]