mefenamic acid

Ligand id: 2593

Name: mefenamic acid

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 241.11
XLogP 5.01
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA. (2001)
MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis.
Cell104 (2): 217-31. [PMID:11207363]
2. Heinrich DM, Flanagan JU, Jamieson SM, Silva S, Rigoreau LJ, Trivier E, Raynham T, Turnbull AP, Denny WA. (2013)
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.
Eur J Med Chem62: 738-44. [PMID:23454516]
3. Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, Meyerhof W, Harteneck C. (2011)
Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3.
Br. J. Pharmacol.162 (8): 1757-69. [PMID:21198543]