phenytoin

Ligand id: 2624

Name: phenytoin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 58.2
Molecular weight 252.09
XLogP 4.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Ragsdale DS, McPhee JC, Scheuer T, Catterall WA. (1996)
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.
Proc. Natl. Acad. Sci. U.S.A.93 (17): 9270-5. [PMID:8799190]
2. Ragsdale DS, Scheuer T, Catterall WA. (1991)
Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.
Mol. Pharmacol.40 (5): 756-65. [PMID:1658608]