T4

Ligand id: 2635

Name: T4

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.78
Molecular weight 776.69
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH. (2006)
Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism.
Mol. Endocrinol.20 (11): 2761-72. [PMID:16887882]
2. Schueler PA, Schwartz HL, Strait KA, Mariash CN, Oppenheimer JH. (1990)
Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3.
Mol. Endocrinol.4 (2): 227-34. [PMID:2158622]