Ligand Id: 2694
Ligand name pioglitazone

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 93.59
Molecular weight 356.12
XLogP 3.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Henke, BR; Blanchard, SG; Brackeen, MF; Brown, KK; Cobb, JE; Collins, JL; Harrington, WW; Hashim, MA; Hull-Ryde, EA; Kaldor, I; Kliewer, SA; Lake, DH; Leesnitzer, LM; Lehmann, JM; Lenhard, JM; Orband-Miller, LA; Miller, JF; Mook, RA; Noble, SA; Oliver, W; Parks, DJ; Plunket, KD; Szewczyk, JR; Willson, TM. (1998)
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
J. Med. Chem., 41 (25): 5020-36. [PMID:9836620]
2. Sakamoto, J; Kimura, H; Moriyama, S; Odaka, H; Momose, Y; Sugiyama, Y; Sawada, H. (2000)
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.
Biochem. Biophys. Res. Commun., 278 (3): 704-11. [PMID:11095972]
3. Young, PW; Buckle, DR; Cantello, BC; Chapman, H; Clapham, JC; Coyle, PJ; Haigh, D; Hindley, RM; Holder, JC; Kallender, H; Latter, AJ; Lawrie, KW; Mossakowska, D; Murphy, GJ; Roxbee Cox, L; Smith, SA. (1998)
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.
J. Pharmacol. Exp. Ther., 284 (2): 751-9. [PMID:9454824]
4. Majeed, Y; Bahnasi, Y; Seymour, VA; Wilson, LA; Milligan, CJ; Agarwal, AK; Sukumar, P; Naylor, J; Beech, DJ. (2011)
Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels.
Mol. Pharmacol., 79 (6): 1023-30. [PMID:21406603]