dihydroergocryptine

Ligand id: 282

Name: dihydroergocryptine

Abbreviated name: DHC

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 114.45
Molecular weight 577.33
XLogP 3.11
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Plassat JL, Amlaiky N, Hen R. (1993)
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Mol Pharmacol44: 229-236. [PMID:8394987]
2. Ruat M, Traiffort E, Leurs R, Tardivel-Lacombe J, Diaz J, Arrang JM, Schwartz JC. (1993)
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Proc Natl Acad Sci U S A90: 8547-8551. [PMID:8397408]
3. Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY et al.. (2013)
Structural Features for Functional Selectivity at Serotonin Receptors.
Science,  [Epub ahead of print]. [PMID:23519215]