dioctanoylglycerol pyrophosphate

Ligand id: 2916

Name: dioctanoylglycerol pyrophosphate

Abbreviated name: DGPP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 22
Topological polar surface area 185.51
Molecular weight 504.19
XLogP 3.34
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

References
1. Fischer DJ, Nusser N, Virag T, Yokoyama K, Wang Da, Baker DL, Bautista D, Parrill AL, Tigyi G. (2001)
Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.
Mol. Pharmacol.60 (4): 776-84. [PMID:11562440]
2. Kano K, Arima N, Ohgami M, Aoki J. (2008)
LPA and its analogs-attractive tools for elucidation of LPA biology and drug development.
Curr. Med. Chem.15 (21): 2122-31. [PMID:18781939]
3. Murakami M, Shiraishi A, Tabata K, Fujita N. (2008)
Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Biochem. Biophys. Res. Commun.371 (4): 707-12. [PMID:18466763]
4. Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Nishitoba T, Im DS, Nochi H, Tamoto K, Tomura H, Okajima F. (2003)
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Mol. Pharmacol.64 (4): 994-1005. [PMID:14500756]
5. Tabata K, Baba K, Shiraishi A, Ito M, Fujita N. (2007)
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
Biochem. Biophys. Res. Commun.363 (3): 861-6. [PMID:17905198]