lorcaserin

Ligand id: 2941

Name: lorcaserin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 12.03
Molecular weight 195.08
XLogP 2.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Halford JC. (2010)
Lorcaserin--not a new weapon in the battle with appetite.
Nat Rev Endocrinol6 (12): 663-4. [PMID:21102648]
2. Jia J, Xiong L, Chen S. (2010)
Trial of lorcaserin for weight management.
N. Engl. J. Med.363 (25): 2468-9; author reply 2469-70. [PMID:21158670]
3. Smith B, Smith J. (2005)
5HT2C receptor modulators.
Patent number: US6953787 B2. Assignee: Arena Pharmaceuticals, Inc.. Priority date: 12/04/2002. Publication date: 11/10/2005.
4. Thomsen WJ, Grottick AJ, Menzaghi F, Reyes-Saldana H, Espitia S, Yuskin D, Whelan K, Martin M, Morgan M, Chen W et al.. (2008)
Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.
J. Pharmacol. Exp. Ther.325 (2): 577-87. [PMID:18252809]
5. von Haehling S. (2010)
Trial of lorcaserin for weight management.
N. Engl. J. Med.363 (25): 2468; author reply 2469-70. [PMID:21158671]