pirenzepine

Ligand id: 328

Name: pirenzepine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 68.78
Molecular weight 351.17
XLogP 1.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
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Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
J. Pharmacol. Exp. Ther.256 (2): 727-33. [PMID:1994002]
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Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo.
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A toxin from the green mamba Dendroaspis angusticeps; amino acid sequence and selectivity for muscarinic m4 receptors.
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Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
J Pharmacol Exp Ther284: 500-507. [PMID:9454790]
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Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
J Pharmacol Exp Ther316: 279-288. [PMID:16188951]
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Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
EMBO J7: 3031-3035. [PMID:2846274]
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Selectivity profile of the novel muscarinic antagonist UH-AH 37 determined by the use of cloned receptors and isolated tissue preparations.
Br. J. Pharmacol.102 (1): 246-50. [PMID:2043926]