5S-HETE   Click here for help

GtoPdb Ligand ID: 3390

Synonyms: 5-(S)-hydroxyeicosatetraenoic acid
Compound class: Metabolite or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 57.53
Molecular weight 320.24
XLogP 6.62
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O
Isomeric SMILES CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O
InChI InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
InChI Key KGIJOOYOSFUGPC-JGKLHWIESA-N
References
1. Grant GE, Rokach J, Powell WS. (2009)
5-Oxo-ETE and the OXE receptor.
Prostaglandins Other Lipid Mediat, 89 (3-4): 98-104. [PMID:19450703]
2. Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T. (2002)
Identification of a novel human eicosanoid receptor coupled to G(i/o).
J Biol Chem, 277 (35): 31459-65. [PMID:12065583]
3. Hosoi T, Sugikawa E, Chikada A, Koguchi Y, Ohnuki T. (2005)
TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis.
Biochem Biophys Res Commun, 334 (4): 987-95. [PMID:16039985]
4. Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P. (2003)
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.
Mol Pharmacol, 63: 471-477. [PMID:12606753]
5. O'Flaherty JT, Cordes JF, Lee SL, Samuel M, Thomas MJ. (1994)
Chemical and biological characterization of oxo-eicosatetraenoic acids.
Biochim Biophys Acta, 1201 (3): 505-15. [PMID:7803484]
6. O'Flaherty JT, Taylor JS, Thomas MJ. (1998)
Receptors for the 5-oxo class of eicosanoids in neutrophils.
J Biol Chem, 273 (49): 32535-41. [PMID:9829988]
7. Patel P, Cossette C, Anumolu JR, Gravel S, Lesimple A, Mamer OA, Rokach J, Powell WS. (2008)
Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity.
J Pharmacol Exp Ther, 325 (2): 698-707. [PMID:18292294]
8. Powell WS, Gravel S, MacLeod RJ, Mills E, Hashefi M. (1993)
Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor.
J Biol Chem, 268 (13): 9280-6. [PMID:8387490]
9. Powell WS, Gravelle F, Gravel S. (1992)
Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes.
J Biol Chem, 267 (27): 19233-41. [PMID:1326548]
10. Schwenk U, Schröder JM. (1995)
5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements.
J Biol Chem, 270 (25): 15029-36. [PMID:7797484]