atrasentan

Ligand id: 3487

Name: atrasentan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 13
Topological polar surface area 88.54
Molecular weight 510.27
XLogP 4.69
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Chiappori AA, Haura E, Rodriguez FA, Boulware D, Kapoor R, Neuger AM, Lush R, Padilla B, Burton M, Williams C et al.. (2008)
Phase I/II study of atrasentan, an endothelin A receptor antagonist, in combination with paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer.
Clin. Cancer Res.14 (5): 1464-9. [PMID:18316570]
2. Nelson JB, Chan-Tack K, Hedican SP, Magnuson SR, Opgenorth TJ, Bova GS, Simons JW. (1996)
Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.
Cancer Res.56 (4): 663-8. [PMID:8630991]
3. Opgenorth TJ, Adler AL, Calzadilla SV, Chiou WJ, Dayton BD, Dixon DB, Gehrke LJ, Hernandez L, Magnuson SR, Marsh KC, Novosad EI, Von Geldern TW, Wessale JL, Winn M, Wu-Wong JR. (1996)
Pharmacological Characterization of A-127722, an orally active and highly potent ETA-selective receptor antagonist.
J. Pharmacol. Exp. Ther.276: 473-481. [PMID:8632312]
4. Salani D, RosanĂ² L, Di Castro V, Spinella F, Venuti A, Padley RJ, Nicotra MR, Natali PG, Bagnato A. (2002)
ABT-627, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma growth in vitro.
Clin. Sci.103 Suppl 48: 318S-321S. [PMID:12193113]
5. Sasser JM, Sullivan JC, Hobbs JL, Yamamoto T, Pollock DM, Carmines PK, Pollock JS. (2007)
Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism.
J. Am. Soc. Nephrol.18 (1): 143-54. [PMID:17167119]
6. Winn M, von Geldern TW, Opgenorth TJ, Jae HS, Tasker AS, Boyd SA, Kester JA, Mantei RA, Bal R, Sorensen BK et al.. (1996)
2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.
J. Med. Chem.39 (5): 1039-48. [PMID:8676339]