CGS 15943

Ligand id: 384

Name: CGS 15943

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 69.87
Molecular weight 285.04
XLogP 2.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Alexander SP, Cooper J, Shine J, Hill SJ. (1996)
Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells.
Br. J. Pharmacol.119 (6): 1286-90. [PMID:8937736]
2. Auchampach JA, Kreckler LM, Wan TC, Maas JE, van der Hoeven D, Gizewski E, Narayanan J, Maas GE. (2009)
Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.
J. Pharmacol. Exp. Ther.329 (1): 2-13. [PMID:19141710]
3. Dionisotti S, Ongini E, Zocchi C, Kull B, Arslan G, Fredholm BB. (1997)
Characterization of human A2Aadenosine receptors with the antagonist radioligand [3H]-SCH 58261.
Br. J. Pharmacol.121: 353-360. [PMID:9179373]
4. Ji X, Kim YC, Ahern DG, Linden J, Jacobson KA. (2001)
[3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors.
Biochem Pharmacol61: 657-663. [PMID:11266650]
5. Ji XD, Jacobson KA. (1999)
Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.
Drug Des. Discov.16: 217-226. [PMID:10624567]
6. Kim J, Wess J, van Rhee AM, Schoneberg T, Jacobson KA. (1995)
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor.
J. Biol. Chem.270: 13987-13997. [PMID:7775460]
7. Kim YC, Ji XD, Jacobson KA. (1996)
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
J Med Chem39: 4142-4148. [PMID:8863790]
8. Klotz K-N, Hessling J, Hegler J, Owman C, Kull B, Fredholm BB, Lohse MJ. (1998)
Comparative pharmacology of human adenosine receptor subtypes characterization of stably transfected receptors in CHO cells.
Naunyn Schmiedebergs Arch. Pharmacol.357: 1-9. [PMID:9459566]
9. Müller CE. (2000)
A2A Adenosine receptor antagonists—future drugs for Parkinson’s disease?.
Drugs Future,  (25): 1043-1052.
10. Ongini E, Dionisotti S, Gessi S, Irenius E, Fredholm BB. (1999)
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.
Naunyn Schmiedebergs Arch. Pharmacol.359: 7-10. [PMID:9933143]
11. Stewart M, Steinig AG, Ma C, Song JP, McKibben B, Castelhano AL, MacLennan SJ. (2004)
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors.
Biochem Pharmacol68: 305-312. [PMID:15194002]
12. Varani K, Merighi S, Gessi S, Klotz KN, Leung E, Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Borea PA. (2000)
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
Mol Pharmacol57: 968-975. [PMID:10779381]