AMG517

Ligand id: 4129

Name: AMG517

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 105.24
Molecular weight 430.07
XLogP 5.41
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Blum CA, Caldwell T, Zheng X, Bakthavatchalam R, Capitosti S, Brielmann H, De Lombaert S, Kershaw MT, Matson D, Krause JE et al.. (2010)
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
J. Med. Chem.53 (8): 3330-48. [PMID:20307063]