europium-labelled relaxin-3-B/INSL5 A chimera   Click here for help

GtoPdb Ligand ID: 4374

Synonyms: Eu-R3/I5 | europium-labelled H3-B/INSL5 A chimera
 Ligand is labelled
Compound class: Peptide or derivative
Comment: Europium-labelled relaxin-3-B/INSL5 A chimera is a chemiluminescent probe analogue of the ligand relaxin-3/INSL5 chimera. It consists of 2 subunits: the B chain subunit of human relaxin-3 and the A chain subunit of human INSL5.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Haugaard-Kedström LM, Shabanpoor F, Hossain MA, Clark RJ, Ryan PJ, Craik DJ, Gundlach AL, Wade JD, Bathgate RA, Rosengren KJ. (2011)
Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3.
J Am Chem Soc, 133 (13): 4965-74. [PMID:21384867]
2. Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA et al.. (2012)
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.
J Med Chem, 55 (4): 1671-81. [PMID:22257012]