Ligand Id: 45
Ligand name naratriptan

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 73.58
Molecular weight 335.17
XLogP 1.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Newman-Tancredi, A., Conte, C., Chaput, C., Verriele, L., Audinot-Bouchez, V., Lochon, S., Lavielle, G. and Millan, M. J. (1997)
Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.
Naunyn Schmiedebergs Arch Pharmacol, 355: 682-688. [PMID:9205951]
2. Wainscott, D. B., Krushinski, J. H., Audia, J. E., Schaus, J. M., Zgombick, J. M., Lucaites, V. L. and Nelson, D. L. (2005)
[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.
Naunyn Schmiedebergs Arch Pharmacol, 371: 169-177. [PMID:15900510]
3. Napier, C., Stewart, M., Melrose, H., Hopkins, B., McHarg, A. and Wallis, R. (1999)
Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.
Eur J Pharmacol, 368: 259-268. [PMID:10193663]
4. Domenech, T., Beleta, J. and Palacios, J. M. (1997)
Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.
Naunyn Schmiedebergs Arch Pharmacol, 356: 328-334. [PMID:9303569]
5. Reynolds, G. P., Mason, S. L., Meldrum, A., De Keczer, S., Parnes, H., Eglen, R. M. and Wong, E. H. (1995)
5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases.
Br J Pharmacol, 114: 993-998. [PMID:7780656]