γ-hydroxybutyric acid

Ligand id: 4711

Name: γ-hydroxybutyric acid

Abbreviated name: GHB

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 57.53
Molecular weight 104.05
XLogP -0.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW. (2009)
Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81.
J Biol Chem.284 (5): 2811-2822. [PMID:19047060]
2. Snead 3rd OC. (2000)
Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor.
J. Neurochem.75 (5): 1986-96. [PMID:11032888]
3. Ticku MK, Mehta AK. (2008)
Characterization and pharmacology of the GHB receptor.
Ann. N. Y. Acad. Sci.1139: 374-85. [PMID:18991884]
4. Wang Q, Darling IM, Morris ME. (2006)
Transport of gamma-hydroxybutyrate in rat kidney membrane vesicles: Role of monocarboxylate transporters.
J. Pharmacol. Exp. Ther.318 (2): 751-61. [PMID:16707723]