LPS   Click here for help

GtoPdb Ligand ID: 5019

Synonyms: lipopolysaccharide derived from Gram-negative bacteria
Comment: Lipopolysaccharides are complex molecules consisting of a core oligosaccharide, lipid A and O antigen (or O polysaccharide) joined by covalent bonds
References
1. Chung S, Kim H, Kim D, Lee JM, Lee CJ, Oh SB. (2022)
Common bacterial metabolite indole directly activates nociceptive neuron through transient receptor potential ankyrin 1 channel.
Pain, 163 (8): 1530-1541. [PMID:34817438]
2. Han Q, Liu D, Convertino M, Wang Z, Jiang C, Kim YH, Luo X, Zhang X, Nackley A, Dokholyan NV et al.. (2018)
miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
Neuron, 99 (3): 449-463.e6. [PMID:30033153]
3. Meseguer V, Alpizar YA, Luis E, Tajada S, Denlinger B, Fajardo O, Manenschijn JA, Fernández-Peña C, Talavera A, Kichko T et al.. (2014)
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.
Nat Commun, 5: 3125. [PMID:24445575]
4. Mukhopadhyay I, Kulkarni A, Aranake S, Karnik P, Shetty M, Thorat S, Ghosh I, Wale D, Bhosale V, Khairatkar-Joshi N. (2014)
Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic.
PLoS One, 9 (5): e97005. [PMID:24819048]
5. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C et al.. (1998)
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.
Science, 282 (5396): 2085-8. [PMID:9851930]
6. Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM, Lu HY, Wang J, Thompson JD, Lickwar CR et al.. (2021)
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.
Cell Host Microbe, 29 (2): 179-196.e9. [PMID:33352109]