propofol

Ligand id: 5464

Name: propofol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 178.14
XLogP 4.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. (2005)
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.
J. Pharmacol. Exp. Ther.315 (2): 517-25. [PMID:16033909]
2. Lyashchenko AK, Redd KJ, Yang J, Tibbs GR. (2007)
Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.
J. Physiol. (Lond.)583 (Pt 1): 37-56. [PMID:17569731]
3. Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS et al.. (2013)
A propofol binding site on mammalian GABAA receptors identified by photolabeling.
Nat. Chem. Biol.9 (11): 715-20. [PMID:24056400]