BRL 37344

Ligand id: 567

Name: BRL 37344

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 78.79
Molecular weight 363.12
XLogP 3.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Blin N, Camoin L, Maigret B, Strosberg AD. (1993)
Structural and conformational features determining selective signal transduction in the beta 3-adrenergic receptor.
Mol Pharmacol.44: 1094-1104. [PMID:7903415]
2. Dolan JA, Muenkel HA, Burns MG, Pellegrino SM, Fraser CM, Pietri F, Strosberg AD, Largis EE, Dutia MD, Bloom JD, et al.. (1994)
Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines.
J Pharmacol Exp Ther.269: 1000-1006. [PMID:7912272]
3. Hoffmann C, Leitz MR, Oberdorf-Maass S, Lohse MJ, Klotz KN. (2004)
Comparative pharmacology of human beta-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells.
Naunyn Schmiedebergs Arch Pharmacol.369: 151-159. [PMID:14730417]
4. Mejean A, Guillaume JL, Strosberg AD. (1995)
Carazolol: a potent, selective beta 3-adrenoceptor agonist.
Eur J Pharmacol.291: 359-366. [PMID:8719421]