AS1535907

Ligand id: 5722

Name: AS1535907

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 64.75
Molecular weight 384.06
XLogP 4.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Negoro K, Yonetoku Y, Maruyama T, Yoshida S, Takeuchi M, Ohta M. (2012)
Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists.
Bioorg. Med. Chem.20 (7): 2369-75. [PMID:22365911]
2. Yoshida S, Ohishi T, Matsui T, Tanaka H, Oshima H, Yonetoku Y, Shibasaki M. (2010)
Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice.
Biochem. Biophys. Res. Commun.402 (2): 280-5. [PMID:20937249]
3. Yoshida S, Ohishi T, Matsui T, Tanaka H, Oshima H, Yonetoku Y, Shibasaki M. (2011)
The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function.
Diabetes Obes Metab13 (1): 34-41. [PMID:21114601]