losartan

Ligand id: 590

Name: losartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 92.51
Molecular weight 422.16
XLogP 7.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Burns CM, Wortmann RL. (2011)
Gout therapeutics: new drugs for an old disease.
Lancet377 (9760): 165-77. [PMID:20719377]
2. de Gasparo M, Whitebread S, Bottari SP, Levens NR. (1994)
Heterogeneity of angiotensin receptor subtypes.  in  Medicinal Chemistry of the Renin-Angiotensin System.
Edited by Timmermanns PBMWM, Wexler RR Elsevier. 269-294  [ISBN:0444820531]
3. Hamada T, Ichida K, Hosoyamada M, Mizuta E, Yanagihara K, Sonoyama K, Sugihara S, Igawa O, Hosoya T, Ohtahara A et al.. (2008)
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients.
Am. J. Hypertens.21 (10): 1157-62. [PMID:18670416]
4. Timmermans PBMWM, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM, Smith RD. (1993)
Angiotensin II receptors and angiotensin II receptor antagonists.
Pharmacol. Rev.45: 205-251. [PMID:8372104]