Synonyms: 5-oxo-15-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoic acid
Compound class:
Metabolite or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Grant GE, Rokach J, Powell WS. (2009)
5-Oxo-ETE and the OXE receptor. Prostaglandins Other Lipid Mediat, 89 (3-4): 98-104. [PMID:19450703] |
2. Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T. (2002)
Identification of a novel human eicosanoid receptor coupled to G(i/o). J Biol Chem, 277 (35): 31459-65. [PMID:12065583] |
3. Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P. (2003)
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol Pharmacol, 63: 471-477. [PMID:12606753] |
4. O'Flaherty JT, Cordes JF, Lee SL, Samuel M, Thomas MJ. (1994)
Chemical and biological characterization of oxo-eicosatetraenoic acids. Biochim Biophys Acta, 1201 (3): 505-15. [PMID:7803484] |
5. O'Flaherty JT, Taylor JS, Thomas MJ. (1998)
Receptors for the 5-oxo class of eicosanoids in neutrophils. J Biol Chem, 273 (49): 32535-41. [PMID:9829988] |
6. Patel P, Cossette C, Anumolu JR, Gravel S, Lesimple A, Mamer OA, Rokach J, Powell WS. (2008)
Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther, 325 (2): 698-707. [PMID:18292294] |
7. Powell WS, Gravel S, MacLeod RJ, Mills E, Hashefi M. (1993)
Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor. J Biol Chem, 268 (13): 9280-6. [PMID:8387490] |
8. Powell WS, Gravelle F, Gravel S. (1992)
Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. J Biol Chem, 267 (27): 19233-41. [PMID:1326548] |
9. Powell WS, MacLeod RJ, Gravel S, Gravelle F, Bhakar A. (1996)
Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol, 156 (1): 336-42. [PMID:8598482] |
10. Schwenk U, Schröder JM. (1995)
5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements. J Biol Chem, 270 (25): 15029-36. [PMID:7797484] |