Abbreviated name: 4-HNE
Synonyms: 4-hydroxy-2-nonenal | HNE
Compound class:
Metabolite or derivative
Comment: 4-Hydroxynonenal is an α,β-unsaturated hydroxyalkenal that is produced by lipid peroxidation in cells, particularly by cells that are under stress.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Kinney WA, Machatha SG, Young S. (2018)
Aldehyde trapping compounds and methods of use thereof. Patent number: WO2018039197A1. Assignee: Aldeyra Therapeutics, Inc.. Priority date: 22/08/2016. Publication date: 01/03/2018. |
2. Macdonald S, Cullen V, Brady T, Levi I, Meilin S, Young S. (2018)
ADX-102, a novel aldehyde trap, reduces nociceptive behavior in mouse models of carrageenan and CFA induced pain. J Pain Relief, Posters & Accepted Abstracts. DOI: 10.4172/2167-0846.C1.012 |
3. Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A. (2007)
An ion channel essential for sensing chemical damage. J Neurosci, 27 (42): 11412-5. [PMID:17942735] |
4. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS et al.. (2007)
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA, 104 (33): 13519-24. [PMID:17684094] |