AMG 9810

Ligand id: 6347

Name: AMG 9810

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 47.56
Molecular weight 337.17
XLogP 6.93
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, Immke D, Wang J, Zhu D, Vanderah TW, Porreca F et al.. (2005)
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
J. Pharmacol. Exp. Ther.313 (1): 474-84. [PMID:15615864]