rivaroxaban

Ligand id: 6388

Name: rivaroxaban

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 116.42
Molecular weight 435.07
XLogP 1.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lu G, DeGuzman FR, Hollenbach SJ, Karbarz MJ, Abe K, Lee G, Luan P, Hutchaleelaha A, Inagaki M, Conley PB et al.. (2013)
A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa.
Nat. Med.19 (4): 446-51. [PMID:23455714]
2. Perzborn E, Roehrig S, Straub A, Kubitza D, Mueck W, Laux V. (2010)
Rivaroxaban: a new oral factor Xa inhibitor.
Arterioscler. Thromb. Vasc. Biol.30 (3): 376-81. [PMID:20139357]