avagacestat

Ligand id: 6489

Name: avagacestat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 127.77
Molecular weight 520.06
XLogP 4.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Alzheimer Research Forum. 
DRUGS IN CLINICAL TRIALS: BMS-708163.
Accessed on 06/09/2013. Modified on 06/09/2013. Alzheimer Research Forum, http://www.alzforum.org/drg/drc/detail.asp?id=124
2. Coric V, van Dyck CH, Salloway S, Andreasen N, Brody M, Richter RW, Soininen H, Thein S, Shiovitz T, Pilcher G et al.. (2012)
Safety and tolerability of the γ-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease.
Arch. Neurol.69 (11): 1430-40. [PMID:22892585]