trametinib

Ligand id: 6495

Name: trametinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 102.06
Molecular weight 615.08
XLogP 4.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Gilmartin AG, Bleam MR, Groy A, Moss KG, Minthorn EA, Kulkarni SG, Rominger CM, Erskine S, Fisher KE, Yang J et al.. (2011)
GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition.
Clin. Cancer Res.17 (5): 989-1000. [PMID:21245089]
2. Yamaguchi T, Kakefuda R, Tajima N, Sowa Y, Sakai T. (2011)
Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo.
Int. J. Oncol.39 (1): 23-31. [PMID:21523318]