methimazole

Ligand id: 6649

Name: methimazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 56.62
Molecular weight 114.03
XLogP 0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Crescioli C, Cosmi L, Borgogni E, Santarlasci V, Gelmini S, Sottili M, Sarchielli E, Mazzinghi B, Francalanci M, Pezzatini A et al.. (2007)
Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes.
J. Endocrinol.195 (1): 145-55. [PMID:17911406]
2. Nakashima T, Taurog A, Riesco G. (1978)
Mechanism of action of thioureylene antithyroid drugs: factors affecting intrathyroidal metabolism of propylthiouracil and methimazole in rats.
Endocrinology103 (6): 2187-97. [PMID:748042]